Key publications by leaders in the RNA field

Evidence for Ligandable Sites in Structured RNA Throughout the Protein Data Bank” Hewitt, William M., et al., Bioorganic & Medicinal Chemistry, published online April 6, 2019.

Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans” Weeks, et al., Biochemistry 2018, 57 (26), 3537–3539.

Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing” Mustoe, et al., Cell 2018, 173, 1-15.

The Emerging Role of RNA as a Therapeutic Target for Small Molecules” Connelly et al., Cell Chemical Biology 2016, 23, 1077-1090.

Modulation of the E. coli rpoH Temperature Sensor with Triptycene-Based Small Molecules” Barros et al., Angew. Chem. Int. Ed. 2016, 55, 8258-8261.

Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells” Childs-Disney & Disney, Ann. Rev. Pharm. Tox. 2016, 56, 123-140.

Toward All RNA Structures, Concisely” Weeks, Biopolymers 2016, 103, 138-148.

SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice” Palacino et al., Nat. Chem. Bio. 2015, 11, 511-517.

Selective small-molecule inhibition of an RNA structural element” Howe et al., Nature 2015, 526, 672-677.

Computational Analysis of Conserved RNA Secondary Structure in Transcriptomes and Genome” Eddy, Ann. Rev. Biophys. 2015, 43, 433-456.

Recognition of Nucleic Acid Junctions Using Triptycene-Based Molecules” Barros & Chenoweth, Angew. Chem. 2014, 126, 13966 –13970.

Transient RNA Structure Features are Evolutionarily Conserved and can be Computationally Predicted” Zhu et al., Nucleic Acids Res. 2013, 41, 6273-6285.

Molecular Interactions That Stabilize RNA Tertiary Structure: RNA Motifs, Patterns, and Networks” Butcher & Pyle, Acc. Chem. Res. 2011, 44, 1302-1311.

RNA Bind-n-Seq: Quantitative Assessment of the Sequence and Structural Binding Specificity of RNA Binding Proteins” Lambert et al., Mol. Cell 2014, 54, 887-900.

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